Patema lives in an underground civilization, where she often explores the vast network of tunnels that connect the surrounding areas. One day, she explores the "Forbidden Zone" and, startled by a noise, falls down a bottomless pit. Patema falls out of the bottomless pit on the surface of the Earth, where she continues to fall into the sky, until saved by a young boy, Age. On the surface, people like Patema, known as "Inverts" are considered sinners. Despite this, Age and Patema form a bond that will help to unravel the mystery of their two civilizations.

Much like Blame!, Patema Inverted explores the consequences of humans' reliance and experimenting with technology. While Blame! sees the backfiring of its technologies resulting in humans being hunted by machines, Patema Inverted has a much less tragic result. An experiment to harness the power of gravity resulted in the two inverted worlds. Like Blame!, Patema Inverted features children's exploration of their world leading to chance encounter that could result in huge changes in their civilization.

In the dilapidated city of Lux, three different groups battle for control of the city referred to simply as "The City" by its citizens because of its apparent mind of its own. Ichise, a prizefighter in Lux, finds himself caught in the center of the struggle for power when he loses an arm and leg. Thanks to Eriko Kamata, Ichise's life is saved and his limbs replaced with newly designed Texhnolyze, prosthetics that are the driving force in Lux's struggle. After meeting Ran, a young girl with the power to see the future, Ichise realizes that they are the only ones that can save The City from its imminent war and collapse.

Texhnolyze, in addition to its "living city," is very similar to Blame! for its dark dystopian imagining of the future. While not fully explored and explained, Killy has what seems to be prosthetics and technological augmentation. The two anime present highly interesting take on a technologically advanced future, and the consequences that may come with them, presented with a great narrative and story-telling and the most fitting of atmospheres.

17 years ago, immortality in humans was first discovered. These immortal people, called "Ajin" were labeled as a threat to mankind. To prevent the destruction they may bring to mankind, whenever a new Ajin is discovered, they are immediately taken into government custody. A hard-working high school student, with dreams of becoming a doctor, Kei Nagai's life takes a turn for the worst when a life-ending accident doesn't end his life. Surviving this accident, Kei becomes aware of the fact that he is an Ajin, and instead of spending the rest of his life in custody opts to go on the run.

Ajin doesn't have nearly the same story or theme as Blame!. Their similarities are immediately noticeable, however, as they both employ a unique CG animation art style. In addition to their similar art styles, both Blame! and Ajin feature top-notch action scenes.

For reasons now unknown to many, thanks to the passage of time, mankind now lives in a sprawling labyrinth of metal. Ura spends his days working in the Archive Extraction Department, where he analyzes and restores old files related to the history of mankind. Due to his curiosity, Ura constantly looks to find more answers than his job requires him to answer. His curiosity proves to be too much when he comes across an archived video. This video leads Ura to finally seek answers that will hopefully help him understand mankind's history.

Pale Cocoon, while lacking the action found in Blame! features the same science fiction regarding the decline and now forgotten the history of mankind. Pale Cocoon is an ambitious attempt to look at what would happen when mankind brings on its own near extinction and creates a disconnect from its own history. Both anime also does a good job of exhibiting a dystopian and drab future for mankind, through their minimal use of bright colors, instead opting for more subdued colors to reflect the desolate future.

No one knows what lies at the bottom of the Abyss, a giant chasm that goes down deep into the earth. The people who explore the Abyss, hoping to uncover its mysteries, are known as Divers. The most celebrated Divers are known as White Whistles. The daughter of one missing White Whistle, Riko hopes to become a White Whistle one day to explore the depths of the Abyss. Despite being restricted to the upper layer of the Abyss, Riko has an encounter with Reg, a robot made with technology that must have originated from the depths of the Abyss. Eager to uncover the mystery of Reg and the Abyss, the two travel to the depths of the chasm.

Made in Abyss, shares with Blame! a tribe of people that explore the mysterious and ever-expanding part of their world. While Blame! is a dark science fiction tale, Made in Abyss features more fantasy than science fiction, as well as a more light-hearted adventure. Still, the two stories tell a great story of a people looking to understand more about the world around them.

Those who know the Matrix will understand exactly how the Animatrix is similar to Blame! The Matrix universe takes place in a time when robots have risen up against humans, and the remaining humans have all fled underground where they continue to be hunted by the machines. If that doesn't already bear striking similarities to Blame!, then perhaps nothing will.

The Animatrix explores parts of the Matrix universe not seen in the movies. This includes "Final Flight of the Osiris," which sees the hovercraft, the Osiris as it is pursued and attacked by an army of Sentinels, "Matriculated," which sees humans hunting down the machines, as well as other stories related to the Matrix. The stories that feel most connected to Blame! are "The Second Renaissance Parts I & II." In the world of Blame! mankind found itself hunted by the automated city, while "The Second Renaissance" tells the story of the robots' uprising against the humans.