Top 10 Mad Scientists in Anime [Updated]

While we can be sure that everyone reading this knows this already, it has to be said whenever an opportunity presents itself – anime is amazing. Being able to go toe-to-toe with other media with regards to themes, genres and even characters, anime very unsurprisingly also has quite the thing for mad scientists! Many of these characters are notable in their respective universes for their scientific impact, while others are mad for… other reasons. Whatever the madness in the scientist is, we’re here to give you ten of the maddest!

10. The Doctor – Hellsing Ultimate

  • Episodes: 10
  • Aired: February 2006 – December 2012

Unbeknownst to many, creatures of darkness and evil lurk in the shadows, ready to pounce on unsuspecting humans. The Hellsing organisation is dedicated to getting rid of these unholy forces and at the top of the organisation is Sir Integra Fairbrook Wingates Hellsing, who commands a powerful military dedicated to fighting the undead. Her army; however, is nothing in comparison to her trump card: Alucard, the vampire. With his new vampire servant, Seras Victoria, Alucard battles all that opposes Hellsing in order to ensure the survival of humankind.

Starting off with the fact that he proudly sports a perpetually bloodstained lab coat on any regular day, we have a mad scientist who possesses immense intelligence… and immense madness. The Doctor was the mind behind the creation of a Nazi vampire army which had a thousand volunteers. Under situations of stress, The Doctor would bite down on his fingers hard enough to draw blood. Yikes!

9. Sucy Manbavaran – Little Witch Academia

  • Episodes: 25
  • Aired: January 2017 – June 2017

Ever since Kagari “Akko” Atsuko watched her idol, the famous witch, Shiny Chariot in a magic performance when she was a child, Akko has aspired to become a witch just like Shiny Chariot. Despite not having a magical background, Akko is determined to become a witch who can use magic to make people smile. However, it proves to be difficult from the jump as the trip to her new school is anything but smooth. After the unpleasant trip to Luna Nova Magical Academy, Akko’s new school and learning environment, she befriends Lotte Yansson and Sucy Manbavaran and also finds Shiny Chariot’s wand, the Shiny Rod, which she claims for herself! Starting off her time with a handicap, Akko realises that succeeding at Luna Nova is going to be a major challenge; however, determination is Akko’s best quality and she aims to use it to the best of its potential.

Sucy is a cynical Southeast Asian witch who specialises in the brewing of potions, which often have bizarre effects. With a blatant disregard for ethics of any kind, Sucy uses her friend Akko as a test subject and sometimes even uses Akko to help her gather some of the dangerous ingredients that she needs to pull off some of her experiments! Sucy’s approach to magic and the related sciences makes all the more sense when one considers how she looks just like a stereotypical witch, with the pale skin to match!

8. Lala Satalin Deviluke – To-LOVE-Ru!

  • Episodes: 26
  • Aired: April 2008 – September 2008

Yuuki Rito is a timid 16-year-old who has had a crush on his fellow classmate Sairenji Haruna since he was in middle school. The situation becomes a little bit interesting when one night, a naked girl crash-lands on Rito during his bath time and it turns out that the mystery girl is Lala Satalin Deviluke, the crown princess of an alien empire! Escaping from an unwanted arranged marriage, Lala marries Rito and so ends his perfectly normal life. With an ever-increasing legion of girls slowly coming to realise the positive elements to Rito’s character, and his own romantic preamble reaping rapid failures, Rito’s life has become infinitely more interesting than ever before.

Despite being the crown princess of the Empire of Deviluke, Lala’s most interesting feature isn’t the fact that she is an alien princess. It is her keen intellect and inventive mind which let her create some of the wackiest, most comical inventions in the entire show! Lala’s genius has helped both herself and Rito out of some of the stickiest situations but with her childish personality and her absent mind, these inventions tend to do a lot more to cause mischief and go haywire almost all the time!

7. Takashima Rei – Deadman Wonderland

  • Episodes: 12
  • Aired: April 2011 – July 2011

Igarashi Ganta’s class was supposed to have an amazing day at Deadman Wonderland, the local prison amusement park, where prisoners do dangerous activities for the entertainment of the masses. However, everything falls apart when every single one of Ganta’s classmates is killed by a man in red. Framed for the murders, Ganta is sentenced to prison in the very Deadman Wonderland his class was supposed to visit. In Deadman Wonderland, Ganta is exposed to a reality of sadistic inmates and the emergence of strange powers all in a ruthless environment where he must participate in deadly games, find the “Red Man” who killed his friends and clear his name.

Giving off the initial impression of a regular doctor who has earned her stripes in the understanding and in-depth care of the human body, Takashima Rei is actually one of the more sadistic characters in Deadman Wonderland. This becomes evident whenever there is a battle between Deadmen. Winner earns themselves a lot of credits and glory perhaps, while the loser often catches a trip to Takashima-sensei’s dentist chair, where the doctor excitedly removes an organ from the loser’s body, often very painfully.

6. Shiguma Rika – Boku wa Tomodachi ga Sukunai (I Don’t Have Many Friends)

  • Episodes: 12
  • Aired: October 2011 – December 2011

Hasegawa Kodaka is a high schooler determined to make a positive impression at his new school and possibly make some friends. Unfortunately for him; however, he is immediately labelled a violent delinquent about a month in due to his intimidating facial expression. Kodaka’s notorious reputation leaves him friendless; however, when he finds fellow loner Mikazuki Yozora talking to herself in an empty classroom, they hit it off over stories of their lonely high school lives. Looking to overcome the difficulties of making friends, Kodaka and Yozora start the Neighbour’s Club. Created for people who have no friends, the daily activities of the club include learning social skills and fitting in; but with each new member bringing a whole new type of eccentricity to the table, maybe social skills and fitting in aren’t exactly all they need to make new friends.

Perverted, eccentric, geeky and perverted is the perverted Shiguma Rika. Initially being saved by Kodaka from a harmless accident in her lab, Rika joins the Neighbours Club, immediately exposing herself as the show’s resident genius, but also its resident pervert. She often goes into highly excited tirades about anything sexual and even goes as far as to say things to make people uncomfortable!

5. Hange Zoe – Shingeki no Kyojin (Attack on Titan)

  • Episodes: 25
  • Aired: April 2013 – September 2013

After being driven to the brink of extinction by the titans, mysterious humanoid creatures that thrive on human flesh, humanity now lives behind a concentric circle of thick walls. In order to survive, humanity assumed life behind these walls and managed to go 100 years without a single encounter with the titans. However, one day, a massive titan manages to break through the outermost wall, restarting humankind’s fight for survival. After suffering a loss at the hands of the titans, young Eren Jaeger dedicates his life to their eradication and joins the Survey Corps branch of the military which is committed to exploring the land beyond the walls. Alongside his childhood friends Mikasa and Armin, Eren joins the bid for the survival of humankind.

One of humanity’s keenest minds is Hange Zoe, the head scientist of the Survey Corps and one of the more significant individuals in the Attack on Titan universe. Her keen mind is perhaps rivalled only by her eccentricity and apparently offbeat sanity. Her desire to help in the fight against the titans is augmented by the fact that she actually finds the titans interesting beyond their terror and carnage – in fact, when there were titans that they’d actually managed to capture, she named them Sawyer and Bean. Hange cried while torturing them – no one in that universe is crying for a titan unless they’re the mad scientist, Hange Zoe!

4. Kurotsuchi Mayuri – BLEACH

  • Episodes: 366
  • Aired: October 2004 – March 2012

15-year-old Kurosaki Ichigo has always been able to see ghosts. After contact with the ghost of a teenage girl, Ichigo’s immense spiritual energy makes him a target for Hollows, evil spirits who were once human souls. However, Ichigo remains blissfully unaware of this until one night, a woman dressed in a black kimono, armed with a katana at her side, appears in his room out of thin air. She claims to be a Shinigami, an entity akin to the Grim Reaper who guides the souls of the departed to the other side. Their initial meeting turns ugly when a Hollow attacks Ichigo’s family and the Shinigami, Kuchiki Rukia, sustains heavy wounds. With their deaths all but sealed, Rukia suggests that Ichigo take some of her powers in order to defeat the Hollow. And on that day, a Shinigami was born.

Perhaps one of the most profound takes on the concept of perfection comes from the mouth of the Gotei-13’s resident mad scientist, Kurotsuchi Mayuri. Mayuri has very little regard for ethics and a very high level of curiosity. These two elements together make Mayuri quite the poster boy for mad scientists everywhere; however, we think it is also how he feels next to nothing about experimenting on himself or others and also has no concern for the sensibilities of those who witness his work. Working hard to improve what he has created and to understand what he does not makes Mayuri an extremely beautiful case in the archetype that is mad scientist.

3. Nina Einstein – Code Geass: Hangyaku no Lelouch (Code Geass: Lelouch of the Revolution)

  • Episodes: 25
  • Aired: October 2006 – July 2007

In 2010, the Holy Empire of Britannia begins to explore its military might, starting off with the conquest of Japan. Renaming the country “Area 11” after its defeat, Japanese citizens become rebels in an attempt to regain their independence. Exiled prince of Britannia, Lelouch Lamperouge, finds himself in the middle of a conflict between Japanese rebels and Britannia’s forces. He escapes only due to the appearance of C.C., a mysterious girl who gives Lelouch the “Geass”, an incredible power which manifests in him as the power of absolute obedience. He then dons a mask and becomes “Zero”, an enigmatic figure leading the Japanese rebels against Britannia, for whom Lelouch bears much resentment.

Known for the notorious “table scene”, Nina Einstein, as per her name, is a genius high schooler who attends the same school as Lelouch. She is shy but incredibly astute. Later, it is revealed that she is also incredibly maniacal, with her racism against the “elevens” fuelling most of her actions. After the death of Euphemia at the hands of Zero, Nina loses her mind and hates the Japanese even more than she did before. Fun fact: just like her namesake, Albert Einstein, Nina contributed to the creation of a weapon of mass destruction, later feeling remorseful at the damage it caused.

2. Dr. Kanou Akihiko – Tokyo Ghoul

  • Episodes: 12
  • Aired: July 2014 – September 2014

Tokyo is a city of intense violence due to the existence of humanity’s only natural predator: the Ghoul. Ghouls are bloodthirsty beings which feed on human flesh to survive, using their human-like appearance to blend in with human society. 18-year-old Kaneki Ken’s date with the beautiful Kamishiro Rize goes horribly wrong when the fellow bookworm turns out to be a Ghoul herself. With Kaneki coming extremely close to death, a freak accident causes Rize to lose her life, but the meeting sets into motion Kaneki’s dark descent into the violent world of the Ghouls where the only philosophy is canis canem edit.

Long story short, this guy is the reason why Kaneki was turned into a ghoul. While it is initially made out to be that Kaneki’s life was in danger and that they needed to use Rize’s organs to keep him alive, the truth is shocking. Kanou Akihiko had been working and experimenting on ghoulification for a long time and even had some failed attempts like Kuro and Shiro, who are introduced in Root A. His madness is quite clear – he was using ghoulification in attempt to prompt the next stage in human evolution. Being the misanthrope that he was, Kanou believed that human beings lack potential and sought to change that with his own hands.

1. Hououin Kyouma – Steins;Gate

  • Episodes: 24
  • Aired: April 2011 – September 2011

18-year-old Okabe Rintarou, self-proclaimed mad scientist, rents out an old room in a building in Akihabara, where he and his friends Shiina Mayuri and Hashida “Daru” Itaru create inventions Okabe dubs “Future Gadgets”. When their “Phone Microwave”, a Future Gadget which turns bananas into a green gel for some odd reason, soon becomes capable of sending emails to the past, the three are given the ability to change history. However, despite the exciting developments, Okabe soon realises the true danger of being able to transcend time.

Self-proclaimed mad scientist Okabe Rintarou assumes the name “Hououin Kyouma” when introducing himself to others. Working much to the effect of a nickname or just a disregarded stage name, Hououin Kyouma is an important element to the character that is Okabe Rintarou for various reasons. For starters, Hououin Kyouma exists in order to make Okabe’s best friend Mayuri happier after the death of her grandmother. Kyouma’s mannerisms and behaviour are extremely cartoonish and quite comical, but “Kyouma” soon ceases to appear after Okabe’s time-travel ordeal.

Final Thoughts

Mad scientists are a forever trope in media and definitely have seen a lot growth and change in the anime medium specifically. With there being so many mad scientist characters, it could get difficult to find one that you like the most, if you like any at all that is. Are there other anime mad scientists you think deserve a little bit of attention? Drop a comment below and let us know all about them!

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]


Author: Hoshi-kun

I’m South African, harbouring an obsession for anything remotely related to Japan, mostly anime, of course. I draw sometimes. Some people call me Naledi, it’s my real name, or something like that. People think I’m stoic because I don’t smile often (I do sometimes). I like languages. Hoshi-kun and Naledi are the same side of the same coin.

Previous Articles

Top 5 Anime by Hoshi-kun

Original Article Below

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

When thinking of Mad Scientists, one can only imagine a character in anime as a crazy, psychotic, shameless individual who only cares about science, progress, calculations, and the outcome of their work.
That is exactly the basis of the anime characters chosen for this list. I will admit, close to none of these characters have all the attributes listed above, but they are too close. Some of these characters represent good and some evil, while a few are just down right crazy without any consideration towards life itself.

Here's the list of the Top 10 Mad Scientists in Anime!

10. Washuu Hakubi from Tenchi Muyo

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]
Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

This character is know as the mad scientist of the universe who possesses supernatural power and is always wanting to be the best.
She is extremely knowledgable in all fields of science, electronics and alternate dimensions. She is capable of accomplishing anything that comes her way, when she puts her mind to it. She can create anything in no time with little to no effort.

But, her reasoning is somewhat obscure, sometimes known to develop weapons of mass destructions and portals to another universe or dimension.
It doesn't seems to bother her in anyway for she sees it as a way of displaying her brilliance.

9. Dr. Gero from Dragon Ball Z

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]
Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

This character is a vengeful, mad scientist, seeking refuge in his laboratory high up in the mountains after the Red Ribbon Army's defeat, Dr. Gero's hatred for Goku, sparks the madness for his experiments of revenge.
Because of Dr. Gero's cold-hearted goals, he is extremely confident in his technological skills and intelligence. After transferring his brain into an android of his own creation, he constructs Android 17 and 18 who later rebel against him due to their strength and intellect.

His madness leads to the destruction of many when he creates Cell, the ultimate android who doesn't gain full capacity, until he consumes android 17 and 18. Dr. Gero's madness succeeds with the belief that his androids will carry out his goals.

8. Miyo Takano from Higurashi no Naku Koro Ni

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]
Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

This character has a twisted personality and shows no restraint when it comes to scaring others with her past.
She is indeed a mad scientist to the point that she sees almost everyone as a test subject for her experiments and research. Truly caring mostly for her grandfather and the research he left behind, she is recognized as a complete maniac.
To the point that her actions sometimes lead to the point of unrealism and are mistaken as jokes, but do not be deceived in any way. Takano documents everything she conducts which includes her scientific theories and likes to share these theories for fun, no matter how inhumane they are.
Talking in a very condescending manner while questioning the loyalty of others, she is hated by all. It almost seems like she considers herself as a God in some ways that make her despicable.

When her mentor dies, she is infatuated with continuing his research, to the point of death!

7. Rintarou Okabe from Steins;Gate

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]
Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

This character is somewhat eccentric and melodramatic. He claims that he is a mad scientist and says so as an introduction to others.
Having some of the traits of a mad scientist like being delusional and paranoid, he invents several gadgets that are sometimes useless, but later on prove to be otherwise. He often engages in situations where others see him talking to himself on the phone or busting out in laughter for no apparent reason.
His paranoia comes in handy as he is fully aware of an unavoidable fate that has him following and saving his friends in several cases. His determination and knowledge is what makes a mad scientist.

One of his famous quotes is, “I am Mad Scientist, it's so cool! Sonuvabi*ch!” And he loves Dr. Pepper!

6. Franken Stein from Soul Eater

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]
Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

This character is one of the craziest scientists ever.
Having psychological problems to the point of losing control and seeing all of humanity in the world, including himself, as a test subject or experiment. He's always thought that way since he was young, and has an urge to dissect things he comes across, even people. Stein has stitches going across his face with the assumption that he experimented and dissected his own face for the greater good of science.

Stein is very strong in a way that something powerful lies dormant within him, and who knows if this was the cause of an experiment that he himself conducted.

5. Caesar Clown from One Piece

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]
Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

This character is very manipulative, conniving, deceptive and shameless when it comes to being a mad scientist.
He has great knowledge in creating weapons of mass destruction that involve chemical mixtures of some of the most complex elements known to man. With these mixtures, he creates deadly poisons that can kill any living thing in an instant. He has also used his abilities to develop an oral substance that can cause extreme repercussions and addictions to the point of anarchy.

To know the lengths of his experiments, he has kidnapped several children using them as test subjects while deceiving them into thinking it's medicine that will heal their non-existent illness.

4. Dr. Stylish from Akame Ga Kill!

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]
Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

This character is a unique mad scientist in a way, classified as not only a scientist, but a perfectionist when it comes to fashion styling.Hence his name, Dr Stylish.
As a person who is very fashionable, it definitely does not take away from his shameless intelligence in being creative with anything technological or ground breaking. He shows concern for his creations that seems like he holds them dear, but actually couldn't care less if its a failure. Like a true mad scientist!

Because of his credentials as a renowned figure, he has gained the trust of many through his illegal experimentations and creations.

3. Shou Tucker from Fullmetal Alchemist

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]
Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

This character is presented as a man who had great knowledge but was unable to prove his intelligence to others.
Out of an act of desperation, he's known as one the scientists to combine science and alchemy in the form of creating a chimera that is capable of speech. Believing that this was regulated by means of just science and magic, Shou in fact used a test subject to create this chimera.
This is where the evilness and madness takes over. Shou had actually used his own daughter to complete the process of creating a chimera that was capable of speech. In doing so, not only did he show no emotion in sacrificing his daughter's life in being the subject of his experiments, he did it in an attempt to gain recognition amongst his peers.

This was an all out sad story that made want to cry!

2. Mayuri Kurotsuchi from Bleach

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]
Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

This character is the epitome of a mad scientist.
He is a master researcher when it comes to problem solving and overcoming any situation that comes his way with an answer that points out its flaw. Seeing most things, including people, as research and showing no respect towards said things or others, he wouldn't hesitate to use those around him to either defeat or accomplish his goals.
He hates perfection, because if everything were perfect, he would have nothing to look forward to as far as science.

Kurotsuchi is is also knowledgable in medicine, and is known to create some of the most sophisticated antidotes and viruses known to man.

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

1. Orochimaru from Naruto

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]
Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

This character is probably the worst of the all in my eyes.
He has the same attributes as many other mad scientists, but on another level. He starts off as being an honest and intelligent individual who later becomes desensitized from all emotions and discovers a way to obtain immortality.
Showing no remorse or shame for those he feels are the perfect test subjects for his experiments in obtaining said immortality, he has been known to manipulate an entire community to do his bidding for the sake of achieving his goals.

He goes to such lengths as to kidnap young children and raising them as test subjects until they are unfit for his accomplishments.

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

There you have it. What do you think about the picks for the Top 10 Ten Mad Scientists in Anime!
Do you agree with these choices? If you think there was a character was missed that should be on this list.

Let us know in the comments below!

Rika-Shiguma-Boku-wa-Tomodachi-ga-Sukunai-Haganai-wallpaper Top 10 Mad Scientists in Anime [Updated]

Editor in Chief

Author: Alfonso "Fonzy" Ortiz

I'm a Geek, Nerd, Writer, and lover of all video games, anime, science, technology and the internet. I previously worked for, a contributing writer as the Japanese Corespondent at and founded a website called! I currently live in Japan as Editor in Chief of Honey's Anime and its very talented writers! I'm down for anything! What do you want to do?

Previous Articles