Reiji Kirio, an ordinary office worker, was suddenly transported into another fantasy world. He didn't get any special skills, like all isekai stories; instead, he gained two skills: "appraisal" and "drug discovery." Using the two skills he has, Reiji decides to open a drugstore and live a slow life.

If you are looking for an anime closer to Isekai Yakkyoku, Drugstore in Another World might be the perfect show. Drugstore in Another World has many similarities to Isekai Yakkyoku. Our main characters find themselves in a fantasy world, have gained medical knowledge, and open a drugstore to help people. This anime thought takes more of a slice-of-life, comedic route. It does not go into much detail about the medicines and diseases like Isekai Yakkyoku.

Tsubasa Kurata was an engineer and modern-day otaku from Japan. After being killed in a tragic car accident, Tsubasa was reborn as Ernest Echivarra, a young boy from a noble family. He quickly discovers the fantasy world he is in also has mecha robots called Silhouette Knights. Living every robot otaku's dream, Ernest uses his skills from his past life and his passion for mecha to make the ultimate robot for himself.

Like Isekai Yakkyoku, Knights & Magic also shows that knowledge about anything, even just one thing, can make a difference in the world. Like Isekai Yakkyoku, our main character Ernest was also a reincarnate and has memories of his past. Instead of medicines, though, Knight & Magic follows the theme of robots, with Ernest having the knowledge and experience to improve or create them. So if you are looking for a sci-fi, isekai style, why not try this anime?

Book-lover Urano Motsu dreams of becoming a librarian. Unfortunately, the dream was cut short after she died in a tragic accident. On her last breath, she prayed that she could read books in her next life. As if her prayers were answered, she suddenly finds herself in another world similar to the medieval era as Myne, a frail 5-year-old girl. As a book lover herself, of course, the first thing she would do is to read books, but what is this?! There are no books! Then she will make them herself, and nothing can stop her!

Ascendance of a Bookworm is on our list because of its many similarities with Isekai Yakkyoku. We have main characters who have reincarnated into another world with memories of their past life, have a passion or knowledge about one thing, and use their memories and experiences to make life better. The big difference between Myne and Farma is that Myne does not have any powers to help her achieve her goal. Despite the difference, this anime is just as enjoyable to watch as Isekai Yakkyoku. We recommend you give this anime a try if you haven't already.

Sei Takanashi was heading home after a long work day when she was suddenly transported into another world. In the Kingdom of Slantania, its citizens lived within the miasma and were terrorized by its monsters. The only way for the Kingdom to live in peace is to destroy the miasma and its monster through the power of the Saint. The problem is that they summoned two candidates for Saint. Left on her own after the prince declared the brown-haired girl as the Saint, Sei found her new passion in making potions and set her sights on joining the Medical Flora Research. Little did she know that the true Saint's power is within her and would influence her new life in the new world.

While the premise follows the usual isekai troupe, The Saint's Magic is Omnipotent follows a similar theme as Isekai Yakkyoku: medicines that help people. Instead of modern-day medicines like Isekai Yakkyoku, it focuses on potions. Sei's passion for learning and researching potions has helped many people, whether she realizes it or not. It echoes with Isekai Yakkyoku, especially when she uses her Saint's ability to make these potions.

19-year-old Kazuya Souma became an orphan after the death of his grandfather. He was suddenly transported to another world in a small called the Elfrieden Kingdom. He discovers that the Kingdom wants him to be a "hero" to fight a demon lord and be a tribute to its allies. Instead, he offered to help the Kingdom improve its economy through administrative reform. Liking his idea, the previous King suddenly declared him the new King and betrothed him to the princess. Now, it's up to Kazuya to find the best talents to get the Kingdom back up on its feet.

If you are looking for something different from medicines, what about a show running a Kingdom using modern-day methods? How A Realist Hero Rebuilt A Kingdom is a part of our list because of its unique storytelling of using administrative reforms to change a Kingdom. Just as Isekai Yakkyoku, our main character, uses the knowledge he studied as an aspiring civil servant to improve the whole Kingdom. Just as Isekai Yakkyoku, this shows us that one does not need special powers to make a difference in the world.

Ryouma Takebayashi endured many hardships in his life until he met three gods who decided to give him a second chance in life. Their goal: is to have him live life however he sees fit. Agreeing with their condition, he woke up in a fantasy world as a child and picked up a new hobby of studying and keeping slimes. After living in solitude for three years, he had a fateful meeting with a ducal family member. They convince him to accompany them to a nearby town, to which he agrees. This starts Ryouma's adventures exploring the new world with his slimes.

You don't need experience and memories from your past life to help you. By The Grace Of The Gods shows that even the experiences from the world the characters are in can help them survive the new world. In Ryouma's case, it's his hobby and passion for studying slimes. While not as serious as Isekai Yakkyoku, this anime still made it to our list because of his specialty in learning slimes and using them to adapt to the new world. So if you are looking for a slice-of-life style, why not try this anime?