The twin sisters, Towa and Setsuna were separated from each other when they were caught in a forest fire as children. Towa goes into the tunnel of Jidaiju and travels through time from the Sengoku period to modern times. She was brought as a daughter of the Higurashi family, related to Kagome, and grows up to become a middle school girl talented in martial arts. Meanwhile, her sister Setsuna, who was left behind in the Sengoku period, works for Kohaku, who is the head of youkai extermination, and makes a living by killing youkai. Moroha is the daughter of Kagome and Inuyasha. She also slays youkai as a bounty hunter and is known as "Moroha the youkai slayer".

It's been 10 years since Towa and Setsuna were separated, and the tunnel of the Jidaiju has opened once again. Towa reunites with Setsuna, who appeared in the present day, but for some reason, she has forgotten about Towa. With Moroha, who came along with Setsuna, joining them, the three "Hanyou no Yashahime" ramp around both the modern age and the Sengoku period.