In the year 20XX, the Earth is ravaged by monsters simply known as “the Enemy of Humanity”. Some of these monsters are highly intelligent and even pass for human beings! Special schools were formed where teenagers with supernatural abilities could hone their skills and stand up as heroes against the deadly threat. The superpowered teenagers came to be known as “the Talented”. Hiiragi Nana is a transfer student who claims to possess mind reading powers and attends a high school for “the Talented”. Nakajima Nanao, on the other hand, is a completely normal teenager who is bullied by every last one of his superpowered classmates save for Nana.

From the very start, Talentless Nana appears to be a replica of Charlotte, right down to the main characters’ school uniforms! The basic premises of both anime are similar, with teenagers developing supernatural abilities and being placed in schools dedicated to teaching them how to hone their powers. Both Charlotte and Talentless Nana begin with a fairly lighthearted feel that soon spirals into something dark and convoluted. One major difference; however, is that in Talentless Nana, the superpowered teenagers are common knowledge to society, while in Charlotte, the special schools existed to protect ability users from scientific prodding and probing at the hands of adults. Charlotte protagonist Otosaka Yuu feigns lacking in ability to keep his a secret, which is the same as the Talentless Nana character Nakajima hiding his true abilities from his fellow classmates.