In big cities, Dagashi shops have practically gone extinct, as they struggle to compete with convenience stores and chain restaurants. This trend has only recently started to make its way to the countryside, so the Shikada family have yet to give up on their sweet shop. Kokonotsu Shikada wants nothing to do with the family business and yearns to pursue a career in manga, but the arrival of Hotaru Shidare throws a wrench in his plans. Hotaru is chasing after Kokonotsu's father, as she believes he has what it takes to join her staff at a world-renowned sweet manufacturer, but Yō will only take the job if Hotaru convinces Kokonotsu to accept the family business. Dagashi Kashi's second season maintains the weird eccentricities of its predecessor but ramps up the tension by introducing a nearby convenience store. Unless Kokonotsu starts taking things seriously, Shikada Dagashi might be going out of business.

At one point during Ramen Daisuki Koizumi-san, the gang visits a trendy restaurant that has a simple mantra stamped on its wall - "No Ramen, No Life." This four-word sentence encapsulates Koizumi's very reason for being, as the pretty blonde high schooler dedicates every moment of her free time to ramen. If she is not eating noodles, then Koizumi cannot be happy, and she has no time to waste on silly things like friendship. Koizumi's aloof behavior captures the attention of Yuu Oosawa, her energetic classmate who, after watching Koizumi eat ramen, becomes entranced by the blonde girl's beauty. Despite constantly rejecting her invitations, Koizumi ends up introducing Yuu and a couple of her friends to the delightful world of Ramen.